The first season of MADtv aired from October 14, 1995, to June 22, 1996, with 19 episodes.

The second season of MADtv aired from September 21, 1996, to May 17, 1997, with 22 episodes.

The third season of MADtv aired from September 20, 1997, to May 16, 1998, with 25 episodes.

The fourth season of MADtv aired from August 29, 1998, to May 22, 1999, with 25 episodes.

The fifth season of MADtv aired from September 25, 1999, to May 20, 2000, with 25 episodes.

The sixth season of MADtv aired from September 23, 2000, to June 23, 2001, with 30 episodes.

The seventh season of MADtv aired from September 22, 2001, to May 18, 2002, with 25 episodes.

The eighth season of MADtv aired from September 14, 2002, to May 17, 2003, with 25 episodes.

The ninth season of MADtv aired from September 13, 2003, to May 22, 2004, with 25 episodes.

The tenth season of MADtv aired from September 18, 2004, to May 21, 2005, with 23 episodes.

The eleventh season of MADtv aired from September 17, 2005, to May 20, 2006, with 22 episodes.

The twelfth season of MADtv was broadcast from September 16, 2006, to May 19, 2007, with 22 episodes.

The thirteenth season of MADtv aired from September 15, 2007, to May 17, 2008, with sixteen episodes.

The fourteenth season of MADtv aired from September 13, 2008, to May 16, 2009, with seventeen episodes.

Seven years after the show ended on FOX (and in celebration of the show's 20th anniversary), MADtv was briefly revived for eight episodes on The CW. Nicole Sullivan, Will Sasso, Ike Barinholtz, Bobby Lee, Debra Wilson, Aries Spears, Alex Borstein, Mo Collins, and Anjelah Johnson returned as guests.