Jonathan Joestar's antagonistic relationship with his adopted brother Dio begins a truly bizarre lineage, which is continued by his grandson Joseph.

Joseph Joestar's grandson Jotaro Kujo has a strange new superpower, which turns out to be connected to the reemergence of old foe Dio Brando.

It's the year 1999, 11 years after Jotaro Kujo's desperate fight against DIO in Egypt. Jotaro meets with Josuke Higashikata, the illegitimate son of his grandfather Joseph Joestar. He discovers that Josuke also has the same "Stand" power and that a new threat is surfacing in Morioh City.

In Naples, Italy, the suspected son of Joestar family arch nemesis Dio dreams of becoming a Gang Star so he can bring down the local mafia from within.

The legacy of the Joestar family continues with Jolyne as she and her companions take on new Stand users behind the bars of Green Dolphin Street Prison.

America, 1890. Johnny Joestar, a genius jockey now paralyzed from the waist down, chases after outlaw Gyro Zeppeli in a tough cross-continent horse race.