Forced to work for a cartel that recently killed her boyfriend, Teresa relies on her street smarts, a loyal friend and a mysterious notebook to survive.

Teresa and Camila become partners and set out to end Epifanio and build their own drug empire. Meanwhile, someone from Teresa's past re-enters her life.

In Season 3, Teresa strikes out on her own, determined to build a new empire for herself. But as enemies old and new close in, she realizes that being Queen will require more work -- and more sacrifice -- than she ever imagined.

In season 4, Teresa expands her empire to the East Coast by taking on the Big Easy—New Orleans, Louisiana. But when new enemies emerge and familial trust is broken, Teresa is forced to make difficult decisions that weigh heavy on her soul.

After the return of a familiar face, Teresa reconsiders her reign as queenpin and tries to stay one step ahead of ruthless gangsters and the CIA.