Nancy Drew is a brilliant teenaged detective whose sense of self had come from solving mysteries in her hometown of Horseshoe Bay, Maine – until her mother’s untimely death derails Nancy’s college plans. Devastated by her mother’s passing, Nancy swears off crime-solving while crossing off the days until she can re-apply to college. But when a socialite is murdered, Nancy finds herself a prime suspect in the crime, along with a group of other teens present at the scene: Nancy’s nemesis from high school, George Fan; a rich girl with a mysterious past, Bess Marvin; Nancy’s secret boyfriend, Ned “Nick” Nickerson, and amiable burnout Ace. The five of them must team up to clear their own names – encountering emotional entanglements and even more mysteries along the way.

Season four begins as Nancy launches a new investigation to find a group of missing bodies from Horseshoe Bay's cemetery that have been dug up and stolen—or have possibly risen. As Nancy is drawn into this ghostly case, a string of unexplained paranormal crimes leads the Drew Crew to believe that the literal sins of the town's past have returned to haunt the living.